Vol. 11, Issue 1, Part D (2025)
Observation of Pongamia pinnata leaves of in-vitro anti-inflammatory activities
Observation of Pongamia pinnata leaves of in-vitro anti-inflammatory activities
Author(s)
Somvati Anuragi
Abstract
Inflammation is a response of living vascularized tissue to damage. Conventional or synthetic pharmaceuticals employed in the management of inflammatory illnesses are insufficient and may occasionally produce severe adverse effects. A variety of herbal medications is advised for the treatment of inflammation without adverse effects. Pongamia pinnata, Pierre (Family: Fabaceae), usually referred to as karanja. The seeds and seed oil of the plant have been documented as effective in treating various inflammatory and infectious diseases, including leucoderma, leprosy, lumbago, muscular and articular rheumatism, and cutaneous conditions such as herpes and scabies, in folk medicine and Ayurveda, a traditional healing system. The anti-inflammatory properties of this plant have been documented for different components across multiple models. This study investigated the anti-inflammatory efficacy of a methanolic leaf extract of Pongamia pinnata and the reference medication Diclofenac sodium, in vitro, utilizing the heat-induced protein denaturation method. The quantities of the leaf extract utilized ranged from 50 to 250 μg/ml. Diclofenac sodium concentrations were 50, 100, 150, 200, and 250 μg/ml. The IC50 values for Diclofenac sodium and the extract were 19.03 µg/ml and 81.32 µg/ml, respectively. The methanolic leaf extract of Pongamia pinnata exhibits significant in vitro anti-inflammatory action, likely mediated by flavonoids, tannins, and alkaloids. This constitutes a fresh discovery. The results scientifically validate the application of Pongamia pinnata leaves in traditional Indian medicine for the treatment of inflammation.
How to cite this article:
Somvati Anuragi. Observation of Pongamia pinnata leaves of in-vitro anti-inflammatory activities. Int J Appl Res 2025;11(1):265-267.