AbstractBackground: Obesity is a significant health issue that impacts various bodily systems, including male reproductive health. There is growing evidence that obesity is linked to male infertility, marked by hormonal abnormalities and reduced semen quality.
Methods: This case-control study assessed reproductive hormone levels and semen quality in obese guys relative to normal-weight controls. Hormonal assays quantified FSH, LH, testosterone, and prolactin, whereas semen analyses evaluated volume, sperm count, motility, morphology, DNA fragmentation, and protamine deficiency.
Results: Obese guys had significantly lower levels of serum FSH, LH, and testosterone, along with higher levels of prolactin. The volume, sperm count, total and progressive motility, and number of abnormal sperm morphologies all decreased down when the semen was looked at. Obese males exhibited a notable rise in sperm DNA fragmentation and a deficiency of protamine. There was a clear connection between BMI and difficulties with reproductive health.
Conclusion: Obesity negatively impacts male reproductive hormones and semen quality, leading to subfertility via endocrine disturbance, compromised spermatogenesis, and heightened sperm DNA damage. These results underscore the essential requirement for weight management therapies in males to enhance reproductive health. Addressing obesity presents significant promise for restoring reproductive problems.
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