Vol. 11, Issue 2, Part C (2025)

We report a case of ocular surface squamous neoplasia (OSSN) in a 66-year-old female presenting with a fleshy mass on the temporal aspect of the left eye for four months, accompanied by redness and foreign body sensation. Her best corrected visual acuity was 6/24 in the right eye and counting fingers at half a meter in the left eye. Examination revealed a leukoplakic, lobulated, immobile lesion measuring 4x3 mm on the temporal bulbar conjunctiva, characterized by hard consistency and abnormal vascularity. The both eye showed nuclear sclerosis grade 1-2 and a normal fundus.

CT orbit revealed lobulated lesion involving infero-medial aspect of anterior surface of sclera showing contrast enhancement with no obvious deeper extensions and negative HIV test. She was treated with Topical 1% 5-fluorouracil 4 times daily for 1 week followed by 3 weeks off-treatment followed by. Excisional biopsy, followed by application of mitomycin C and cryotherapy and later with amniotic membrane graft on her left eye. Histopathological report revealed moderately differentiated invasive squamous cell carcinoma that extended horizontally and deeper into the surgical margins. During the 6-month follow-up visit, no clinical evidence of recurrent squamous cell carcinoma was observed.