Vol. 1, Issue 5, Part D (2015)

Abstract
Menopause is associated with adverse changes in bone turnover. When bone resorption exceeds formation, bone loss and osteoporosis will occur. This is explained by Biochemical marker of bone turnover profile. Though Bone Mineral Density (BMD) measurements are the gold standard in calculating bone mass, the changes are usually late and the damage is irreversible. Combined use of biochemical markers of bone turnover helps in early identification of women who are at increased risk of fractures. rnObjective: To compare Serum Total Alkaline Phosphates (ALP), Total Calcium, Urinary OHP in postmenopausal cases and pre-menopausal controls. rnMethods: The study included 25 healthy postmenopausal women as cases, and 25 healthy Premenopausal women. Estimation of ALP was done by kinetic method Recommended by International Federation of Clinical Chemistry (1FCC), Serum total Calcium by modification of Ortho- Cresolphthalein Complexone (OCPC) method, Urinary OHP by modified Neumann and Logan method. rnResults: Bone formation markers, serum total ALP was significantly increased (p<0.001) and total calcium was significantly decreased (p<0.001) in postmenopausal women compared to premenopausal women. Bone resorption marker, urinary OHP was significantly increased (p<0.001) in postmenopausal womenrnConclusion: This study concluded that, Serum total ALP, total calcium and Urinary OHP combined together provided a fairly useful index of bone resorption in postmenopausal women and these common biochemical parameters can be used to categorize postmenopausal women into rapid and slow bone losers. Preventive measures like calcium supplementation or Hormone replacement therapy can be initiated early in those who are rapid bone losers and prevent the osteoporotic fractures.