International Journal of Applied Research
Vol. 2, Issue 4, Part F (2016)
Biochemical evaluation and hypoglycemic activity of ethanolic extract of Xanthium strumarium L. on normoglycemic and alloxan-induced diabetic mice
Sheeraz Ahmad, Sajad H Wani and Shabir Ahmad Lone
The aim of present study was to evaluate the hypoglycemic activity of some fractions of ethanolic extracts in normal and diabetic rats as a step toward activity directed isolation of the hypoglycemic component. Spectral analysis were used for structural determination of isolated compound (II).Oral administration of ethanolic extract and isolated compound-II (300 and 500 mg/kg bw) for 14 days resulted in a significant reduction in blood sugar level. The effect was compared with 10mg/kg (i.p.) Glibenclamide. Alloxan-induced hyperglycemic rats were used for the evaluation of antidiabetic activity. The effect of ethanolic extracts and compound-II on normal and alloxan-induced hyperglycemic rats were compared. The results shows Antihyperglycemic activity of ethanolic extract and compound-II were in dose dependent manner. The activity was more for 500mg/kg bw dose in comparision with 300mg/kg bw for both and compound-II showed better reduction of blood glucose level compared to ethanolic extracts.
How to cite this article:
Sheeraz Ahmad, Sajad H Wani and Shabir Ahmad Lone. Biochemical evaluation and hypoglycemic activity of ethanolic extract of Xanthium strumarium L. on normoglycemic and alloxan-induced diabetic mice. International Journal of Applied Research. 2016; 2(4): 397-402.