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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

Impact Factor: RJIF 5.2

International Journal of Applied Research

Vol. 3, Issue 9, Part E (2017)

Lipid peroxidation, copper and vitamin C in lens and serum of people with diabetes and senile cataracts: A comparative evaluation

Author(s)
Prajna D’Silva, May D’souza, Nelly Nazrath, Arnadi Ramachandrayya Shivashankara, Sucharitha Suresh, V Soumya and Manjeshwar Shrinath Baliga
Abstract
Background: Oxidative stress is implicated in the pathogenesis of diabetic cataract. Copper, known to be a pro-oxidant and vitamin C, an antioxidant, and have far reaching implications in pathogenesis and therapeutic approach to cataract. This study is aimed at comparing the lipid peroxidation, copper and vitamin C levels in diabetic cataract and senile cataract patients.
Methods: In this hospital-based study, cataracts of grade I nuclear stenosis and above were included. Study subjects were forty eight patients with senile cataract and twenty six patients with diabetic cataract. In serum and lens homogenate, levels of malondialdehyde (MDA), the marker of lipid peroxidation, copper and vitamin C were assayed with standard spectrophotometric methods.
Results: Levels of copper, MDA were significantly higher, and vitamin C level was significantly lower in the lens of diabetic cataract patients when compared to senile cataract patients. The levels of MDA and copper in serum did not differ significantly between the two groups. Serum vitamin C was significantly lower in diabetic cataract group when compared to senile cataract patients.
Conclusions: We observed oxidative stress in the lens of diabetic cataract patients indicated by increased lipid peroxidation and copper, and decreased vitamin C. Future studies with larger sample size and involving antioxidant treatment of cataract are required.
Pages: 294-297  |  325 Views  6 Downloads
How to cite this article:
Prajna D’Silva, May D’souza, Nelly Nazrath, Arnadi Ramachandrayya Shivashankara, Sucharitha Suresh, V Soumya and Manjeshwar Shrinath Baliga. Lipid peroxidation, copper and vitamin C in lens and serum of people with diabetes and senile cataracts: A comparative evaluation. International Journal of Applied Research. 2017; 3(9): 294-297.
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