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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

Impact Factor: RJIF 5.2

International Journal of Applied Research

Vol. 6, Issue 6, Part C (2020)

Molecular docking, synthesis, characterisation and in vitro anti-mitotic evaluation of some novel pyrrole and pyrazole derivatives of purine

Author(s)
Vijaya Kumar P, Yadati Narasimha Spoorthy and LK Rvindranath
Abstract
Hydrazinyl purine derivatives react with acetonyl acetone in presence of glacial acetic acid in alcohol form respective pyrrole derivatives. Hydrazinyl purine derivatives react with acetyl acetone in presence of catalytic amount of hydro chloric acid in water form respective pyrazole derivatives. The structures of these compounds have been established by 1H NMR studies, IR studies and Mass data. This docking study explores the anti-mitotic activities of pyrrole and pyrazole derivatives of purine. The result from the docking study showed that pyrazole derivatives had excellent anti-mitotic activity that was comparable to the activity of abacavir.
Pages: 136-156  |  32 Views  4 Downloads
How to cite this article:
Vijaya Kumar P, Yadati Narasimha Spoorthy and LK Rvindranath. Molecular docking, synthesis, characterisation and in vitro anti-mitotic evaluation of some novel pyrrole and pyrazole derivatives of purine. International Journal of Applied Research. 2020; 6(6): 136-156.
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