Vol. 1, Issue 11, Part C (2015)

Abstract
Context: Evaluating analgesic activity of Achyranthes aspera, by comparing with standard drugs morphine and piroxicam. Aim: To study the anti-nociceptive activity of Achyranthes aspera linn in experimental animal models. rnMethod and Material: peripheral analgesic model by writhing syndrome and central analgesic model by tail flick method. Materials required are plant leaves, healthy albino rats, drugs like morphine and piroxicam, tail flick analgesiometer. Statistical analysis used: graph pad software and ANOVA test. Result: In acetic acid induced writhing syndrome methanolic extract was decreased 14.365 to 39.57% reduction in writhing numbers after single oral administration of 600 and 900 mg/kg body weight, respectively, which were significantly higher (p ≤ 0.001) than control group. In the tail flick test reaction time was increased significantly (p ≤ 0.001) from 30 to 60 minutes after single oral administration of Achyranthes aspera 600& 99 mg/kg. Conclusion: Methanolic extract of Achyranthes aspera was shown significant anti-nociceptive activity in peripheral and central experimental models. But it shown less activity than standard drugs.