International Journal of Applied Research
Vol. 1, Issue 2, Part C (2015)
Evaluation of anti-inflammatory activity of ethanolic extract of leaves of Clerodendrum serratum Linn. in experimental animals
The present study was conducted to evaluate the anti-inflammatory activity of Clerodendrum serratum Linn. The anti-inflammatory activity was done by in-vivo model i.e. the carrageenan induced rat paw edema model. The standard drug diclofenac sodium (500mg/kg) has significantly reduced paw oedema volume by0.15±0.02 at 1st hr, 0.18±0.01 at2nd hr, 0.25 ±0.02 at 3rd hr and 0.3 at±0.02 at 4th hr, thus standard drug has exhibited time dependent reduction in oedema volume. The ethanolic extract with a dose of 200mg/kg b.w has significantly reduced oedema volume by 0.18±0.03, 0.25 ±0.0.02, 0.28. ±0.01, 0.35±0.03 at 1st, 2nd, 3rd and 4th hrs respectively which was found to be a time dependent effect. At the end of 4 hours in test group treated with 200mg/kg b.w of ethanolic extract showed inhibitory effects of 37.5% respectively.
How to cite this article:
Malik Tafazul Rashid, Shabir A Lone, Sajad H Wani, AS Yadav. Evaluation of anti-inflammatory activity of ethanolic extract of leaves of Clerodendrum serratum Linn. in experimental animals. Int J Appl Res 2015;1(2):165-168.