Vol. 1, Issue 7, Part N (2015)

Background and Objectives: The objective is to examine the haematological results and establish a connection with the clinical progression, assess the significance of platelet count in forecasting the prognosis in individuals with dengue, and monitor the number of patients who test positive for dengue and require platelet transfusion, as well as the resulting outcome.

Methods: A total of 70 individuals who were admitted with fever and tested positive for IgM and/or NS1 were chosen. The study examined a range of haematological, biochemical, and clinical characteristics, as well as the impact of platelet transfusion on the observed outcomes. A comprehensive statistical study was conducted on the different parameters.

Results: The study included a total of 70 cases, all of which exhibited fever (100%), headache (100%), myalgia (71%), hepatomegaly (50%), and splenomegaly (43%).31% of the patients exhibited ascites, whereas 19% showed an increase in haematocrit and pleural effusion. 75% of the cases exhibited leukopenia, while 27% of the cases demonstrated a reversal in the neutrophil lymphocyte ratio. The levels of AST and ALT were elevated, with an average value of 106.08 IU/L and 118.54 IU/L, respectively. In 86% of the instances, platelet transfusion was deemed necessary. On the initial day, transfused platelets accounted for 62% of the cases.1-2 units of platelets were transfused in 54% of the cases. A total of 58.49% of the patients experienced a recovery period of three days following platelet transfusion.

Conclusion: Dengue fever should be strongly suspected when a patient presents with symptoms such as fever, headache, thrombocytopenia, leukopenia, reversal of neutrophil lymphocyte ratio, as well as evidence of capillary leakage including ascitis, pleural effusion, and increasing haematocrit. The utilization of platelet transfusion in instances of moderate to severe thrombocytopenia has demonstrated its efficacy in facilitating a successful and seamless recuperation process.