International Journal of Applied Research
Vol. 2, Issue 1, Part G (2016)
Phytochemical investigation and Antiinflammatory activity of aqueous extract of leaves of Clerodendrum serratum Linn.
The present investigation was carried out to find the effect of aqueous extract of leaves of Clerodendrum serratum Linn. for antiinflammatory activity in rodents. The aqueous extract of Clerodendrum serratum Linn. With a selected dose of 200mg/kg b.w have exhibited a significant reduction in paw oedema volume in carrageenan induced paw oedema in rats at different time intervals. The standard drug diclofenac sodium (500mg/kg) has significantly reduced paw oedema volume by 42.30% at 1st hr, 45.45% at 2nd hr, 41.86% at 3rd hr and 46.42% at 4th hr, thus standard drug has exhibited time dependent reduction in oedema volume. The ethanolic extract with a dose of 200mg/kg b.w has significantly reduced oedema volume by 11.53%, 15.15%, 23.25% and 28.57.% and 19.14% at 1st, 2nd, 3rd and 4th hrs respectively which was found to be a time dependent effect. At the end of 4 hours in test group treated with 200mg/kg b.w of aqueous extract showed inhibitory effects of 28.57% respectively.
How to cite this article:
Malik Tafazul Rashid, Sajad H Wani, Shabir A Lone, AS Yadav. Phytochemical investigation and Antiinflammatory activity of aqueous extract of leaves of Clerodendrum serratum Linn.. Int J Appl Res 2016;2(1):468-472.