International Journal of Applied Research
Vol. 2, Issue 10, Part K (2016)
Serum cystatin C: A prognostic marker in lupus nephritis
Systemic Lupus Erythematosus, commonly known as “Lupus or SLE”, is an inflammatory disease of connective tissue and immune system, where we find organs and cells undergo damage initially mediated by tissue-restricting auto antibodies and immune complexes. Our aim was to evaluate the association of Serum Cystatin C in lupus nephritis patients and validate its use as a prognostic marker.
Material and Methods: We studied the level of Serum Urea, Creatinine, Urinary Albumin-Creatinine Ratio (ACR), 24 hours Urine Protein and Serum Cystain C) in SLE without nephritis and Lupus Nephritis patients. Any change after 6 months was noted and correlation of Serum Cystatin C with disease activity scores (SLEDAI) was done.
Results: Comparison of Serum Cystatin C level in the cases showed higher value at the first visit (2.50 ± 1.21) judge against the follow up visit at 6 months (1.03 ± 0.47). This variation was found statistically significant (P value < 0.001). Comparison of Serum Cystatin C level at first visit showed higher value in cases group (2.50 ± 1.21) compared to control (0.70 ±0.26) group. This difference was highly statistically significant (P value <0.001). Mean age of the study participant in the cases group was found 30.43 ± 7.29 years (ranging from 18 to 52 years) where as it was 29.85 ± 9.22 years (ranging from 18 to 58 years) in the control group.
Conclusion: Serum level of Cystatin C among adult Lupus Nephritis patients were higher than adult Non-renal SLE patients and can be used as a prognostic marker and may guide the treatment.
How to cite this article:
Jyoti Ranjan Parida, Anindya Brahma, Subhashree Ray, Jatindra Nath Mohanty, Pradeepta Sekar Patro. Serum cystatin C: A prognostic marker in lupus nephritis. Int J Appl Res 2016;2(10):740-743.