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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

Impact Factor: RJIF 8.4

International Journal of Applied Research

Vol. 2, Issue 11, Part H (2016)

Preparation and characterization inclusion complexes of fluorouracil α –CD / HP α – CD

Author(s)
A Glory Punitha and J Prema Kumari
Abstract
Solubility of poorly water soluble drugs is an important aspect of formulation and development. Fluorouracil is an anticancer drug with a small molecular weight. The absorbance and fluorescence spectra were record. Absorption maxima of Fluorouracil is blue shifted by the addition of α-cyclodextrin and Hydroxy propyl α- cyclodextrin. The fluorescence maxima are red shifted for both α –CD and HP α - CD. The association constant K is higher which confirms that the drug molecule completely include in to the α-Cyclodextrin cavity. The phase solubility study implies the formation of AL type diagram. The solubility of the drug increases with increase in concentration of both CDs. Thin layer chromatography studies were carried out. The drug fluorouracil is highly soluble in ethyl acetate- water mixture. The high Rf value proves that the drug is included strongly in the HPα-CD cavity. The obtained inclusion complex is the type with equimolar ratio1:1.
Pages: 539-543  |  620 Views  15 Downloads
How to cite this article:
A Glory Punitha, J Prema Kumari. Preparation and characterization inclusion complexes of fluorouracil α –CD / HP α – CD. Int J Appl Res 2016;2(11):539-543.
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International Journal of Applied Research