International Journal of Applied Research
Vol. 2, Issue 12, Part K (2016)
PH-metric studies on 2-p-chlorophenyl thiocarbamidophenol with different transition metal ions in 70% mixed solvent media
DT Tayade and SO Mohod
Stability constant is an effective parameter in pharmacodynamics and pharmacokinetic study of molecules. The medicinal properties of any molecule are checked after synthetic process for that various physical methodologies are used. Late work highlight pH-metric investigation of proton-ligand and metal-ligand stability constant of 2-p-Chlorophenylthiocarbamidophenol with various transition metal ion at 0.1 M ionic strength in 70% ethanol-water mixture by Irving-Rossotti method. It is observed that different transition metal ions forms 1:1 complex with 2-p-Chlorophenyl -thiocarbamidophenol. The information acquired was used to estimate and compare the values of proton –ligand stability constant (pK) and metal-ligand stability constants (logk). The effects of substituent’s were studied from the evaluated information (pK and logk).
How to cite this article:
DT Tayade, SO Mohod. PH-metric studies on 2-p-chlorophenyl thiocarbamidophenol with different transition metal ions in 70% mixed solvent media. Int J Appl Res 2016;2(12):698-700.