International Journal of Applied Research
Vol. 2, Issue 2, Part F (2016)
Analysis of codon and amino acid usage pattern in four replicons of radiation-resistant bacterium Deinococcus radiodurans- A challenging factor for waste cleanup & new industrial approach
Partha Majumder, Anjana Mazumdar, Amitabha Kar, Sufal Halder
The complete genetic code of the world’s most radiation resistant organism - the bacteria, Deinococcus radiodurans - has been detailed by researchers at The Institute for Genomic Research (TIGR). This strain of pink bacteria can survive in 1.5 million rads of gamma irradiation - 3,000 times of the amount that would kill a human. The organism’s ability to repair the DNA damage in a day and go on living offered inspiration to carry on research to know the mechanisms of cellular repair. Advances in this area could improve the understanding of cancer, which can be caused by unrepaired DNA damage. Genetically engineering of this microbe could lead to improved ways to clean up pollution (especially, waste cleanup) and to new industrial processes. Besides the insights into the way cells work, this new research may help to provide a new safe and inexpensive tool for some of the Nation’s most difficult clean up challenges.In this paper of research work we have analyzed how really the high radiation resistant of D.radiodurans strain R1 makes it an ideal candidate for bioremediation of the sites, which are contaminated with radiation and toxic chemicals, it is also naturally transformable and therefore amenable to genetic manipulation. On cultivation of with the bacteria D. radiodurans, we found that hydrophobicity, expressivity and aromaticity are the major sources of variation in amino acid usage among the genes in the organism makes it compatible to survive itself even in adverse condition of nature compared to other organisms.
How to cite this article:
Partha Majumder, Anjana Mazumdar, Amitabha Kar, Sufal Halder. Analysis of codon and amino acid usage pattern in four replicons of radiation-resistant bacterium Deinococcus radiodurans- A challenging factor for waste cleanup & new industrial approach. Int J Appl Res 2016;2(2):342-344.