International Journal of Applied Research
Vol. 2, Issue 2, Part F (2016)
Positive biofeedback of Crb3 protein favouring notch mediated tumour suppression in human body: A glimpse for better understanding of cancer biology and to identify potential therapeutic targets
Our study is a comprehensive approach of a biofeedback paying regards to homeostasis of human body. A biofeedback system involves a sensory organ and an appropriate stimulus. The stimulus is mediated through organs derived from specific biosensors. Homeostasis is the set of processes by which constant or static conditions are maintained within the internal environment of a subject and therefore a homeostat is a controller involved in maintaining homeostasis. Paying regards to extensive study on Cytology, we found that, Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity is considered both a hallmark and precondition for human cancer. According to our knowledge, three conserved polarity protein complexes regulate different modes of polarity that are conserved throughout numerous cell types and species. These complexes are the Crumbs, Par and Scribble complex. Defects in apical-basal polarity regulation are associated with tissue overgrowth and tumorigenesis. Recent studies performed on different vertebrates showing that apical polarity proteins of the Crumbs family act to repress tissue growth and epithelial to mesenchymal transition. Therefore, these proteins associated as potential tumor suppressors. Moreover, extensive analysis of the molecular function of Crumbs proteins reveals a function for these polarity regulators in junctional complexes stability and control of signaling pathways regulating proliferation and apoptosis. Thereby, aim of our in-depth study is to unwind a molecular basis explaining how regulation of epithelial polarity is coupled to tumorigenesis which will be really beneficial for Human Civilization.
How to cite this article:
Partha Majumder, Anjana Mazumdar. Positive biofeedback of Crb3 protein favouring notch mediated tumour suppression in human body: A glimpse for better understanding of cancer biology and to identify potential therapeutic targets. Int J Appl Res 2016;2(2):370-381.