International Journal of Applied Research
Vol. 2, Issue 3, Part H (2016)
“Solid as Solvent”- Novel spectrophotometric analysis of metronidazole tablets using solids (Eutectic Liquid of Phenol and Metformin Hydrochloride) As Solubilizing Agents (Mixed Solvency Concept)
The present experiment is a research to show that solid can also be used as solvents in various spectrophotometric methods. In present study we are using eutectic mixture of Phenol and Metformin hydrochloride (PMHCl 41) which is obtained by trituration of crystals of phenol and metformin hydrochloride employed to dissolve Metronidazole from fine tablet triturate powder. Distilled water is used for dilution to carry out spectrophotometric analysis at 320nm without using any toxic and carcinogenic organic solvents. The solubility of Metronidazole in distilled water at room temperature was found to be 7.28 mg/ml while the solubility of Metronidazole in PMHCl 41 was more than 130mg/ml. This new miraculous approach can be used in day to day spectrophotometric analysis of compounds. The corresponding approach is accurate and reproducible. The method provides safe and ecofriendly way for the estimation of the compound. The accuracy, reproducibility and precision of the method were confirmed by recovery studies and statistical data. The presence of excipients, eutectic mixture (PMHCl 41) did not interfere in spectrophotometric analysis estimation at 320nm. PMHCl 41 does not interfere above 300nm. Proposed method was found to be novel, economic, eco-friendly, rapid, free from toxicity of organic solvent, accurate and reproducible.
How to cite this article:
RK Maheshwari, Priyanka Vaswani, Rohit Adhav, Toshika Jain. “Solid as Solvent”- Novel spectrophotometric analysis of metronidazole tablets using solids (Eutectic Liquid of Phenol and Metformin Hydrochloride) As Solubilizing Agents (Mixed Solvency Concept). Int J Appl Res 2016;2(3):468-469.