International Journal of Applied Research
Vol. 2, Issue 6, Part B (2016)
A histopathological study on the liver of common carp Cyprinus carpio exposed to sublethal concentrations of phorate
The effect of chronic sublethal concentrations of phorate on the histology of liver in the common carp, Cyprinus carpio (C. carpio) was investigated in the present study. Fish were exposed to chronic sublethal toxicity (one-tenth of the LC50/96 hours - 0.071 ppm/l) of phorate (CSTP) for 1, 7, 15 and 30 days and the differential toxicity tests were carried out under laboratory conditions. On exposure for a period of 1 day to CSTP, no significant changes were observed in the structure of the liver. After 7 days of exposure, some degenerative changes like nuclear hypertrophy, vacuolization and karyolysis were observed in the hepatic cells of the liver. Focal necrotic changes were seen in the liver cords with the degeneration of the hepatocytes. On exposure for a period of 15days, the disintegration of liver cords, focal necrosis, degeneration of hepatocytes and karyolysis with widespread vacuolar appearance were noticed in the liver of the fish. On exposure for a period of 30 days to CSTP, further increase in the structural degeneration with increased vacuolization was observed in the liver. A severe degree of atrophy of the liver cords and cytoplasmic disintegration appeared. The liver was disrupted due to the rupture of the cell membranes. The findings of the present study demonstrate that the frequency of pathological changes in the liver of the fish C. carpio, increase with the increasing exposure time to CSTP.
How to cite this article:
G Lakshmaiah. A histopathological study on the liver of common carp Cyprinus carpio exposed to sublethal concentrations of phorate. Int J Appl Res 2016;2(6):96-100.