Herbal and polyherbal formulations are at boom owing to lesser side effects and higher efficacy and are considered for management of renal complications. The present study evaluates the renoprotective effect of flavonoid rich fraction of Helicteres isora
(L.) fruit in gentamicin induced nephrotoxicity wistar rats.
Methods: Nephrotoxicity were induced in wistar rats of either sex by intraperitoneal administration of gentamicin 80 mg/kg body weight for ten days. The extract of flavonoid rich fraction of Helicteres isora (L.) fruit (100, 200, 400 mg/kg) was suspended in 2% w/v gum acacia and administered orally to gentamicin treated rats for next ten days. Rats were subjected to evaluate biochemical and oxidative parameters and histopathology of renal tissue were performed at the end of ten days treatment.
Results: The elevated serum creatinine, uric acid, urea, blood urea nitrogen levels, oxidative stress of kidney and reduced levels of urine creatinine, glomerular filtration rate in gentamycin treated rats were reverted back approximately near to normal after the treatment of flavonoid rich fraction of Helicteres isora (L.) fruit at a doses of 100, 200 and 400 mg/kg.
Conclusion: Flavonoid rich fraction of Helicteres isora (L.) fruit possesses protective action against gentamicin induced nephrotoxicity in wistar rats which may be attributed by its antioxidant effect.