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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 3, Issue 1, Part L (2017)

A comprehensive approach to the treatment of atherosclerosis by increased ApoA-I and HDL-cholesterol levels

Author(s)
Dr. Amitabha Kar
Abstract
In human body, cholesterol is transported around in the form of lipoprotein (lipid/protein) complexes, because it is almost insoluble in water. Extensive study shows that High-density lipoprotein (HDL) particles transport cholesterol from tissues back to the liver for excretion. Epidemiological studies have shown an inverse relationship between blood levels of HDL-cholesterol (HDL-c) and the incidence of clinically significant atherosclerosis. The beneficial effects of HDL in altering atherosclerotic disease are believed to involve elevated levels of HDL enhancing the efflux of cholesterol from arterial walls, increasing transport of cholesterol from arteries to the liver for excretion. This reverse cholesterol transport (RCT) pathway is used to explain both HDL’s role in lipid metabolism and the inverse association between HDL-c plasma concentration and the risk of cardiovascular disease. Based on the RCT model, ApoA-I is an attractive target for therapeutic intervention. Experimental manipulations to increase production of ApoA-I have been associated with reduced atherogenicity. There is a continuing need for novel therapies that increase the biosynthesis of HDL, to inhibit the progression of and even bring about regression of atherosclerosis. Small molecule compounds that increase the production of endogenous ApoA-I would be attractive therapeutic agents for treating dyslipidemias.
Pages: 840-847  |  872 Views  8 Downloads
How to cite this article:
Dr. Amitabha Kar. A comprehensive approach to the treatment of atherosclerosis by increased ApoA-I and HDL-cholesterol levels. Int J Appl Res 2017;3(1):840-847.
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