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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 3, Issue 3, Part C (2017)

Histological outline of renal disease in type 2 diabetes mellitus patients at our hospital

Author(s)
Ashok Kumar Panda and Nisith Kumar Mohanty
Abstract
Renal involvement is a common complication in type-II Diabetes mellitus and it has emerged as the leading cause of end stage renal disease. This study was carried out by taking all patients of T2DM, who underwent renal biopsies at IMS and Sum hospital from January 2016 to February 2017. Seventy-one (Males: 47, Females: 24) subjects with T2DM; who experienced renal biopsy; with a doubt of non-diabetic renal disease were included. The signs for renal biopsy were: acute on chronic renal failure (ACRF) (35.2%), nephrotic syndrome (NS) (31%), acute renal failure (ARF) (14.1%), nephritic syndrome (14.1%), rapidly progressive renal failure (RPRF) (4.2%) and subnephrotic proteinuria (1.4%). The prevalence rates of nondiabetic renal disease (NDRD), diabetic nephropathy (DN) and DN with NDRD were 50.71, 28.16 and 21.13% respectively. The mean durations of T2DM were 12.45, 12.13 and 5.33 years in patients with DN, DN & NDRD and NDRD, respectively. Extensive spectrum of glomerular diseases was detected among those with isolated NDRD; commonest being IgA nephropathy (IgAN) (9.86%), followed by infection related glomerulonephritis (IRGN) (7.04%), membranous nephropathy (MN) (5.63%), focal segmental glomerulus sclerosis (FSGS) (4.22%) & miscellaneous (14.1%) lesions. The acute interstitial nephritis (AIN) was the commonest of the tubule-interstitial diseases (TIDs) in those with isolated NDRD. Among the patients with DN with associated NDRD, acute tubular necrosis (ATN) (7.04%) and IRGN (5.63%) were the shared associated lesions. This study emphasizes the significance of renal biopsy in patients of T2DM with different features.
Pages: 176-180  |  370 Views  6 Downloads
How to cite this article:
Ashok Kumar Panda, Nisith Kumar Mohanty. Histological outline of renal disease in type 2 diabetes mellitus patients at our hospital. Int J Appl Res 2017;3(3):176-180.
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