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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

International Journal of Applied Research

Vol. 3, Issue 7, Part D (2017)

Evaluation of effect of selective plants on diarrhea in experimental animal model representing chronic diarrhoea in malnourished children

Author(s)
Savak Jasmina S, Vaidya Shashikant P, Deshpade Sunita D And Kar Saraswathy
Abstract
There is a marked negative relationship between diarrhoea and physical growth and development of a child. Ayurveda literature indicates that the decoction of processed Zingiber officinale (sunthi), Cyperus rotundus (musta), Cuminum cyminum (jeera) can be used as an anti-diarrhoeal home remedy. In order to find out their activity, a systemic study of these medicinal plants is very important. We have made an attempt to prepare suitable condition in animal model representing chronic diarrhoea in malnourished children and to study in vivo effect of above mentioned plant drugs considering various parameters like colony count of intestinal organisms and organisms of mesenteric lymph nodes, barrier mucosal content of the intestine and histopathological examination of jejunum and ileum that is change in villous morphology and villous height and incidence of cryptitis. Plant extract was prepared by Hot water decoction method. Total eight groups of experimental animals were made. Test groups received high and low doses of plant extracts. In all three plant drugs, there was definitely less translocation of intestinal flora from small intestine to mesenteric lymph nodes in test group animals than in disease control group animals. High dose of all three plant drugs was more effective towards protection of translocation of intestinal flora of small intestine to mesenteric lymph nodes. Maximum effective protection was observed by musta, followed by sunthi and jeera on comparison. There was reduction in gastrointestinal mucosal damage. In colony count of mesenteric lymph nodes shows no bacterial growth, which indicates that translocation of bacteria from intestine to mesenteric lymph nodes, has not occurred. Thus translocation of indigenous intestinal flora into the systemic circulation is prevented. Test animals with High dose showed more mucus content values in all three drugs tested, than disease control and low dose test animals. Mucus content values in low dose test animals was less than disease control animals in jeera and sunthi, where as musta values were more in test animals than disease control animals. Hence, in comparison, musta was observed more effective than jeera and sunthi to control mucus content level in Ileum and Jejunum. Histopathological examination of small intestine tissue test animals showed slight change in shape of villi, anatomy of villi, altered Crypt : villi, and incidence of cryptitis on comparison with Healthy control animals. These results shows usefulness of musta, sunthi, and jeera in antidiarrhoeal model and Musta is found to be a potent antidiarrhoeal drug.
Pages: 247-252  |  729 Views  14 Downloads
How to cite this article:
Savak Jasmina S, Vaidya Shashikant P, Deshpade Sunita D And Kar Saraswathy. Evaluation of effect of selective plants on diarrhea in experimental animal model representing chronic diarrhoea in malnourished children. Int J Appl Res 2017;3(7):247-252.
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