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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF


Vol. 3, Issue 8, Part A (2017)

Study of biochemical changes in gestational diabetes mellitus

Study of biochemical changes in gestational diabetes mellitus

Dr. Eadala Suresh, Dr. GBVVSV Prasad
Background: Pregnancy induces progressive changes in maternal carbohydrate metabolism. As pregnancy advances insulin resistance and diabetogenic stress due to placental hormone necessitate compensatory increase in insulin secretion. When this compensation is inadequate gestational diabetes develops. According to ADA, approximately 7% of all pregnancies are complicated by Gestational Diabetes Mellitus.
Aim: The aim of this study to estimate Glycated hemoglobin, Microlbumin and Lipid profile in Gestational Diabetes mellitus.
Materials and methods: 50 GDM cases were compared with age and sex matched 50 normal control groups for estimation of HbA1c, microalbumin along with lipid profile, and data obtained was statistically analysed.
Results: Fasting plasma glucose levels, plasma glucose levels 1 hour, and plasma glucose levels 2 hours after 75 gm oral glucose administration (oral glucose tolerance test) were significantly higher in patients with gestational diabetes as compared to controls. Glycated hemoglobin was observed to be statistically increased (p<0.0001) and cholesterol, triglycerides, increased significantly. Micro-albumin levels lies within normal ranges in GDM cases.
Conclusion: Our study shows abnormal glucose levels, an HbA1c, cholesterol and triglycerides level which plays a role in GDM. Early diagnosis of gestational diabetes provides safe baby and motherhood and in particular it will reduce the severity of complications, mainly foetal and maternal morbidity and mortality.
Pages: 03-08  |  971 Views  96 Downloads
How to cite this article:
Dr. Eadala Suresh, Dr. GBVVSV Prasad. Study of biochemical changes in gestational diabetes mellitus. Int J Appl Res 2017;3(8):03-08.
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