Vol. 3, Issue 9, Part I (2017)

Abstract
Despite an extensive understanding of T2DM, its management is always difficult in terms of both prevention of occurrence and treatment after incidence. The present study aims at determining the preventive and protective effects of bioactivity-guided fractions of Vigna radiata and Allmania nodiflora in streptozotocin-treated rats fed with a high-fat diet. The bioactive extracts of Vigna radiata and Allmania nodiflora were administered at both 20 mg/kg and 40 mg/kg doses each for 28 days and the changes in the blood glucose, insulin and leptin levels were measured to determine the effects of the treatment on T2DM. Additionally, serum lipid profile and atherogenic index were evaluated to assess the influence on insulin resistance. The results showed that treatment with Vigna radiate and Allmania nodiflora ameliorated the elevated blood glucose levels and this effect correlates with the changes in insulin and leptin levels. Moreover, there was a dose-dependent decrease in the total low-density lipoprotein, triglycerides, and very-low-density lipoprotein levels, indicating the protective effect of the bioactive fractions of Vigna radiate and Allmania nodiflora.