Vol. 4, Issue 1, Part D (2018)

Abstract
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. The desire of the improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) and Solid dispersion technique have received ever increasing demand during the last few decades and the field has become a rapidly growing area in the pharmaceutical industry. The oral bioavailability of BCS class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. A variety of dosage forms like tablets, films, wafers, chewing gums, microparticles, nanoparticles etc. have been developed for enhancing the performance attributes in the orally disintegrating systems. This review depicts the various aspects of MDT formulation and various preparation techniques for solid dispersion.