Anti-Mullerian hormone (AMH), a glycoprotein, is a member of the transforming growth factor-β superfamily and helps in regulation of folliculogenesis and follicular atresia in the ovaries. Follicle stimulating hormone (FSH) is also a glycoprotein that stimulates the growth of ovarian follicles .Thus, they can be considered useful for prediction of ovarian response.
Aim: To determine whether AMH and FSH levels play a role as markers of ovarian response and to find the significance of one over the other.
Material and Methods: A total of 50 women with ovarian factor infertility were enrolled in the study. Blood samples were collected on Day 2 or 3 of cycle for measurement of serum AMH and FSH levels. First cycle of induction with 100mg clomiphene citrate was given and number of leading follicles (> or = 14mm diameter) were counted. Cases with less than 3 leading follicles were subjected to second cycle of induction where along with 100mg clomiphene citrate, 150 IU of Inj. HMG (human menopausal gonadotrophin) was given and number of leading follicles counted. Development of less than 3 follicles at the end of second cycle were considered as poor response.
Result: A total of 50 patients participated in the study. The mean difference of AMH between good responders and bad responders was 3.74±0.62 with a p- value of 0.030, which is statistically significant and the mean difference of FSH between both the groups was 4.16±0.28 with a p- value of 0.001, which highly significant.
Conclusion: Both AMH and FSH are good predictors of poor ovarian response. Further, FSH is better than AMH in predicting the ovarian pool.