International Journal of Applied Research
Vol. 4, Issue 10, Part A (2018)
Activity of garlic extract against the Cryptococcal isolates obtained from cerebrospinal Fluid from patients suffering from fungal meningitis
Cryptococcosis is increasing due to an ever rising population of immunocom promised subjects, including AIDS patients. Ayurveda, the ancient medical science of India requires today documentary evidence to establish for its regular use as remedy, which will be useful for the control and cure of the various infectious conditions. Garlic, has been reported as effective treatment for Cryptococcal meningitis. Keeping in mind the above facts, the study was conducted to evaluate susceptibility of Cryptococcus isolates against Garlic extract in Nair Hospital, Mumbai, including 180 patients, who were clinically suspected for fungal meningitis. Collection and microbiological analysis of cerebrospinal fluid for identification of Cryptococcal isolates was carried out as per standard procedures. Garlic extract was prepared and its Minimum Inhibitory and Lethal concentration was ascertained. Total 20 cases of Cryptococcus species obtained in the study was evaluated against antifungal agents and garlic extract. Highest susceptibility was shown by the Amphotericin B to 60% of the strains. MIC values against garlic extract fell in the range of 128 to 256 mcg/ml, while MLC values in the range of 256 to 512 mcg/ml. Hence by comparing the present study findings it can be suggested that Garlic can help in augmentation of antifungal drugs effect in the treatment of Cryptococcosis.
How to cite this article:
Mathure TV, Vaidya SP, Deshpande SD, Koppikar GV. Activity of garlic extract against the Cryptococcal isolates obtained from cerebrospinal Fluid from patients suffering from fungal meningitis. Int J Appl Res 2018;4(10):17-22.