International Journal of Applied Research
Vol. 4, Issue 10, Part E (2018)
Prognosis of human immunodeficiency virus infected patients with Cryptococcal meningitis
The incidence of and mortality related to Cryptococcal meningitis (C. m.) remain exceedingly high worldwide. With advent of HIV, C. m. cases are on rise along with prognosis of patients. Hence observations were made of prognosis of patients with HIV positive and negative status suffering from C. m. at Nair Hospital, Mumbai. The study included 180 patients, clinically suspected for fungal meningitis. Screening for HIV of these patients was done by rapid diagnostic kits and interpreted according to NACO guidelines. Also identification of Cryptococcus isolates from CSF samples was carried out by standard procedures. 25% and 75% of cases were HIV positive and negative respectively. C. m. was diagnosed significantly higher in HIV positive cases as compared to HIV negative cases. Male preponderance was observed in present study. Maximum number of isolates were sensitive to Amphotericin B as compared to Fluconazole. Out of total 22 patients with C. m. 5 cases showed mortality. Out of which 4 were HIV positive and one was HIV negative. While 17 cases with C. m. were discharged which were then failed to have follow up. Out of which, 15 were HIV positive and two were HIV negative. Our study concludes that Cryptococcus neoformans var neoformans was the most prevalent strain causing fungal meningitis in HIV positive patients. New point-of-care testing and follow up modules have potential to improve early diagnosis and treatment of C. m.in resource-limited settings markedly, however, substantial barriers exist in adhering to the accepted guidelines.
How to cite this article:
Dr. Trupti V Mathure, Dr. Shashikant P Vaidya, Dr. Sunita D Deshpande, Dr. Geeta V Koppikar. Prognosis of human immunodeficiency virus infected patients with Cryptococcal meningitis. Int J Appl Res 2018;4(10):364-368.