Present study was designed to know the prevalence of hypovitaminosis D, and the effect of vitamin D supplementation during third trimester of pregnancy among pregnant women and their new-borns attending Govt. Maternity Hospital, Tirupati. Of the 382 women who were recruited for the study and received vitamin D supplementation, 107 women had complete data. Out of 214 women recruited for control group 110 women had complete data. Both groups are compared for serum 25(OH) D at term, cord blood 25 (OH)D maternal plasma PTH at term, Maternal calcium on day 3 and Anthropometric measurements of the new-borns. The main outcome measured was prevalence of hypovitaminosis D among pregnant women and their new-borns.
1. Both groups were comparable with age, no. of pregnancies, height and weight at term in kg.
2. Both groups were comparable with duration of sun exposure and daily supplement of calcium during pregnancy .
3. Though the duration of sun exposure was high in the control group their serum 25(OH) D level at term was low compared to cases.
4. The serum 25(OH) D level of cases at term was not much increased when compared to their base line.
5. Neonatal serum PTH in control group was high compared to cases, suggesting some physiological role of vitamin D .
6. Birth weight, head circumference, and mid upper arm circumference was higher in babies of vitamin D supplemented group and anterior fontanelle diameter was greater in babies of unsupplemented group .
7. The prevalence of hypovitaminosis D among pregnant women in supplemented group was 76.63% and in unsupplemented group was 87.27% and in the new-borns it is 54.2% and 75.54 % respectively.