International Journal of Applied Research
Vol. 4, Issue 3, Part H (2018)
New approach of the synthesis of β-ketoesters
In the presence of sodium acetate, the reaction between 2,2,6-trimethyl-4H-1,3-dioxin-4-one and secondary or tertiary alcohols (including chiral ones) or primary or secondary amines could be carried out in refluxing tetrahydrofuran, under much milder conditions than those described in the literature. In these new conditions, side products normally observed using the traditional protocol were avoided and β-keto esters were normally obtained in quantitative yields.
How to cite this article:
Amrita Raj. New approach of the synthesis of β-ketoesters. Int J Appl Res 2018;4(3):505-506.