Vol. 4, Issue 6, Part D (2018)

Abstract
Atenolol is a selective β₁ receptor antagonist, a drug belonging to the group of beta blockers. It is a relatively polar hydrophilic compound with water solubility. In the present study, the influence of nature and concentration of selected super disintegrants and lubricants on the hardness. Dissolution kinetics of all the formulations was determined. Due to variation in the physicochemical properties of the super disintegrant and lubricants, variation was observed in the dissolution rate of the drug from tablet to tablet. Sodium starch glycolate at 6% w/w concentration significantly improved the dissolution rate of Atenolol when compared with the other super disintegrants studied. Among the three lubricants used, magnesium stearate at 1.25% w/ w concentration showed rapid drug release.