International Journal of Applied Research
Vol. 4, Issue 7, Part C (2018)
Study of mucocutaneous manifestations of HIV in 526 seropositive patients attending a tertiary care centre in Gujarat
Muco-cutaneous manifestations of HIV/AIDS develop in more than 90% of HIV infected patients. They are amongst the first recognized clinical manifestations of HIV/AIDS and acts as good clinical markers for assessment of patient’s immune status as well as CD4 count. Dermatological manifestations of HIV usually present with atypical clinical spectrum and may co-exist with other pathologies.
Objective: The study was conducted with the primary objective of studying the prevalence of various muco-cutaneous manifestations of HIV/AIDS, their relationship with CD4 count and side effect of anti-retroviral therapy (ART).
Materials and Methods: A hospital based cross sectional study was conducted during July 2011 to June 2014 which enrolled a total 526 HIV/AIDS -positive patients. Study patients were screened for various muco-cutaneous manifestations of HIV/AIDS and ART along with their correlation with CD4 count. The data was analysed by Chi-square test and SSPF software.
Results: Total 713 muco-cutaneous manifestations occurred with an average of 1.35/ patient. Infections were most common manifestation compared to non-infectious manifestations; it constituted 69.71% and 29.58% respectively. Viruses (34.64%) were most common infectious agents followed by fungal infections (17.11%). Majority of events were seen at 200-500 cells/µl CD4 count. Nevirapine was the most common anti-retroviral drug causing cutaneous side effects.
Conclusion: The study results suggest that even though infections were the most frequent cause of muco-cutaneous manifestations in HIV positive patients, we observed a shift in the most common infectious agents from fungi to viruses. A similar kind of shift was also observed in STI from bacterial STI to viruses being the commonest causative agents. Even though ART has increased the life expectancy in these patients, it also exposes them to diverse side-effects
How to cite this article:
Dr. Archana Lokhande, Dr. Santosh Kumar Mahto, Dr. Amita Sutaria, Dr. Bela J Shah. Study of mucocutaneous manifestations of HIV in 526 seropositive patients attending a tertiary care centre in Gujarat. Int J Appl Res 2018;4(7):169-178.