Vol. 4, Issue 9, Part D (2018)

Background and objective: To assess the effectiveness of autologous platelet-rich fibrin (PRF) compared to saline dressing in patients suffering from chronic venous leg ulcers.

Method: A prospective randomized controlled trial was conducted using an open label approach, involving patients diagnosed with chronic venous leg ulcers, from July 2017 to June 2018. Following the acquisition of consent from the ethics committee, the current study was conducted, involving 13 patients.

Result: The patient population consisted of 5 females (27% of the total) and 8 males (73%). The group that received PRF treatment had a notable decrease in ulcer size in comparison to the saline group. At the conclusion of a four-week period, the PRF group exhibited a mean reduction in ulcer area of 87.95%, whereas the saline group had a reduction of 44.89%.

Conclusion: The findings of our research demonstrate a significant and noteworthy reduction in ulcers among individuals who were administered PRF dressings, in comparison to the cohort treated with saline, following a period of 4 weeks. The efficacy, simplicity, patient-friendliness, cost-effectiveness, painlessness, and outpatient nature of Platelet Rich Fibrin dressings make them a highly useful adjunctive therapy for the treatment of persistent venous ulcers. The technique outlined above demonstrates significant potential in achieving thorough closure of ulcers and can be successfully included as a standard procedure for the treatment of venous ulcers.