AbstractAim and Objective:
Analysis of pharmacotherapy and drug related problems in patient with arterial hypertension in Udaipur
Background: Arterial hypertension or high blood pressure is a chronic medical condition which is characterized by elevated blood pressure in the arteries and is an important risk factor for future development of cardiovascular disease. Also belongs to asymptomatic diseases because it usually does not cause symptoms for years until a vital organ is damaged. Moreover is a major cause of morbidity and mortality, due to its association with some other serious diseases like coronary heart disease, cerebrovascular disease, atherosclerosis, renal disease, dyslipidemia, diabetes, obesity and metabolic syndrome. Arterial hypertension for adults, who don’t suffer from any other kind of diseases, is defined by an elevation of blood pressure to 140 / 90 mm Hg or to higher values.
Methods: 55 patient cases were collected regarding age, gender, pharmacotherapy, dosage scheme, strength and adverse drug reaction which were subjected to statistical analysis also.
Results: The present retrospective study was done with 55 patient cases. Hypertension most prevalently affects the male than female. Most common co-morbidities along with hypertension were dyslipidemia and coronary heart disease. Most frequently used antihypertensive drug groups was β- blockers and angiotensin II receptor blockers (alone or in combination with hydroclorothiazide) along with antidyslipidemics as additive to antihypertensive therapy. Commonly noticed adverse drug reactions were bradycardia, fatigue, peripheral edema and dry cough, mainly due to β-blockers, amlodipine and angiotensin-converting-enzyme- inhibitors. Additionally increased levels of creatine phosphokinase and myalgia were observed mainly due to statins, as additive to antihypertensive therapy for management of co-morbidities, like dyslipidemia.
Conclusion: Data on 55 hypertensive patient cases was collected from dept. of Medicine. This study represents the distribution of this problem in population and the different adverse drug reactions on patients under study. This study can be used a model to treat patients with described problems. Further investigations it will be necessary in the future to produce more accurate and representative findings.