AbstractAim and Objective:
Biochemical marker of lipid peroxidation (MDA) and antioxidants level (vitamin C and vitamin E) in young infertile women of reproductive age group.
Introduction: Infertility is defined as the inability of couples to conceive a clinical pregnancy after 12 months or more of unprotected intercourse. It is estimated that 25% of couple will experience an episode of infertility in their reproductive life. Infertility is a medical problem that affect a vast proportion of the world’s young population (10%-15%). Advances in assisted reproductive technologies, such as IVF, can offer hope to many couples where treatment is available, although barriers exist in terms of medical coverage and affordability.
Material and methods: Detailed data was collected about name, age, urban/rural residence, height, weight, medical history including obstetrics & gynaecological history were taken. Other information such as history of smoking, alcoholism, were noted. Informed consent was obtained from each patient before sample collection. The study was approved by PMCH ethical committee. Blood sample was investigated for various parameters like TBARS (MDA) and Vitamin C and Vitamin E.
Results and discussion: In our study there were all adult young females. None of the individuals were below the age of 15 years. In this study, a significant increase in plasma MDA level was observed in patient compared to control (p< 0.001). A significant decreased level of vitamin C and vitamin E was observed in patient group compared to control group (p< 0.001). The results indicate that infertile women have increased serum level of MDA and decreased serum levels of vitamin C and vitamin E as compared to fertile women.