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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

International Journal of Applied Research

Vol. 5, Issue 6, Part A (2019)

Clinico-morphological spectrum and diagnostic efficacy of fine needle aspiration cytology in enlarged lymph nodes: A hospital based study of 1053 cases

Author(s)
Dubey Ajita, Sangeeta Sharma, Shweta Chawla Grover, Rani Bansal and Anjali Khare
Abstract
Introduction: Fine Needle Aspiration Cytology (FNAC) is simple, cheap, useful and minimally invasive diagnostic tool for enlarged lymph node lesions. The present study has been undertaken to emphasize the Clinico-cytomorphological spectrum and to determine the diagnostic efficacy of FNAC in enlarged lymph nodes.
Material and Methods: A 5 year hospital based cross-sectional observational study of 1053 patients was conducted, with all relevant clinical details and FNAC was performed and dry and wet smears were prepared and stained. Ziehl-Neelsen (ZN) Staining was done wherever required. The cytomorphological features were correlated with the concomitant histopathological findings, wherever available.
Results: A total of 1053 cases were studied, with slight female preponderance of 51.6%. Out of 1053 cases, 972 were non neoplastic cases while 81 were neoplastic. Cervical group of lymph. Nodes was most commonly involved (628/1053 cases). Maximum number of aspirates were reported as Chronic non-specific lymphadenitis 32.9% (346/1053 of total). Among the neoplastic lesions (81/1053), majority of cases were of metastatic squamous cell carcinoma 42/81 (51.85%). In non-neoplastic lesions, chronic non-specific lymphadenitis and reactive lymphadenitis was most frequently seen in first decade of life, 114/346 cases and 59/182 cases respectively. Whereas tubercular lymphadenitis were more common in 21-30 years age group (101/265 cases) followed by 11-20 age group (80/265cases). Among the neoplastic cases, Metastatic squamous cell carcinoma was most commonly seen in 5th decade. Hodgkin’s lymphoma was more common in 11-20 years age group (4/11cases), whereas Non-Hodgkin’s lymphoma was maximum in 41-50 years age group (5/15cases).Out of 1053 aspirates, histopathological confirmation was available in 20 lymph node lesions. FNAC findings were correlated with histopathological diagnosis in 85% (17/20) cases. The sensitivity, specificity, positive predictive value and negative predictive value of FNAC of lymph nodes were 77.78%, 100%, 100% and 84.62% respectively. The diagnostic accuracy was 90%.
Conclusion: FNAC is an efficient minimally invasive diagnostic method for early diagnosis of enlarged lymph nodes.
Pages: 33-38  |  371 Views  3 Downloads
How to cite this article:
Dubey Ajita, Sangeeta Sharma, Shweta Chawla Grover, Rani Bansal, Anjali Khare. Clinico-morphological spectrum and diagnostic efficacy of fine needle aspiration cytology in enlarged lymph nodes: A hospital based study of 1053 cases. Int J Appl Res 2019;5(6):33-38.
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