Dengue viral infection has become one of the major public health issue worldwide affecting 50-100 million people each year. There are there forms of dengue fever (DF) based on the severity. Early detection and differentiation is the key to prevent the infection.
Aims and Objectives: To assess the hepatic and biliary involvement with severity in Dengue.
Materials and Methods: Hundred patients were studied at the department of Medicine Gandhi Medical College and Hamidia Hospital, Bhopal after dividing in to Dengue Fever (DF; n=74), Dengue Haemorrhagic Fever (DHF, n=13) and Dengue Shock Syndrome (DSS, n=13). All patients were subjected to detailed clinical history, systemic examination, routine investigations along with liver function test (LFT) as well ultrasonography of abdomen.
Results: Dengue was more prevalent in young working age group (61%) females (75%). DF (73.4%) was more prevalent. Fever, rashes and bleeding tendency were more common in severe form of dengue. Majority of patients had elevated liver enzymes, with AST being more elevated than ALT. Patients with hepatomegaly had high total serum bilirubin (1.50±0.90, p=0.005), there were significant elevations in ALT, ALP and Hypoalbuminemia in patients who had hepatomegaly.
Conclusion: GB; gall bladder. derangement is seen more commonly in severe case of dengue infection. Early recognition of these parameters can also be used as a predictor for assessing the disease severity.