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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

Vol. 6, Issue 1, Part C (2020)

A correlative study of serum adenosine deaminase (ADA) and liver function test (LFT) in untreated and treated patients of pulmonary tuberculosis

A correlative study of serum adenosine deaminase (ADA) and liver function test (LFT) in untreated and treated patients of pulmonary tuberculosis

Author(s)
Dr. Nita Sahi, Dr. Gautam Kumar Sharma, Dr. Sangeeta Gurjar and Dr. Ashutosh Meena
Abstract
Aim and Objective: Correlation between Adenosine Deaminase (ADA) and Liver Function Tests in untreated and treated patients of pulmonary tuberculosis.
Introduction: Tuberculosis as a chronic granulomatous disease caused by Mycobacterium tuberculosis usually affects the lungs but all other system as well. Transmission usually takes place through the airborne spread of droplet nuclei produced by patients with infectious pulmonary tuberculosis.
Material and Method: Detailed data was collected regarding age, sex, socioeconomic status & history of the disease etc. Serum Adenosine Deaminase activity and Liver function test was determined by standard method after taking sample from subjects.
Result and discussion: Among 50 healthy controls, there were 25 males (50%) and 25 females (50%), most of them in the age group (21-50) years. The mean serum ADA activity in control was observed to be 15.7 + 4.43 U/L. No significant difference in serum ADA activity was observed in control subjects with respect to age and sex. In untreated phase, the serum ADA activity was observed significantly higher than healthy control (36.4 + 16.9, p<0.001) and treated pulmonary tuberculosis patients too (19.4+ 4.92, p<0.001). The serum activities of the liver enzymes (SGOT, SGPT and ALP) were found significantly higher in treated patients compared to untreated patients of Pulmonary Tuberculosis (61.5+47.39 v/s 23.1 + 7.1; 61.80 + 46.97 v/s 28.03 + 8.04; 157.9 + 67 v/s 91.1+ 21.10, p< 0.001)respectively.
Conclusion: Thus, it can be concluded that serum ADA activity is increased in untreated patients of pulmonary tuberculosis and liver enzymes-ALT, AST and ALP activity increased in treated patients of pulmonary tuberculosis. No significant difference in activities of liver enzymes-ALT, AST and ALP in untreated cases of PTB and control subjects were found.
Pages: 177-180  |  568 Views  91 Downloads


International Journal of Applied Research
How to cite this article:
Dr. Nita Sahi, Dr. Gautam Kumar Sharma, Dr. Sangeeta Gurjar, Dr. Ashutosh Meena. A correlative study of serum adenosine deaminase (ADA) and liver function test (LFT) in untreated and treated patients of pulmonary tuberculosis. Int J Appl Res 2020;6(1):177-180.
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