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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

Vol. 6, Issue 4, Part B (2020)

Study of the relationship between expression of Retinoic acid receptor: Beta by IHC in different grade of oral squamous cell carcinoma

Study of the relationship between expression of Retinoic acid receptor: Beta by IHC in different grade of oral squamous cell carcinoma

Author(s)
Dr. Deepika Pandey, Dr. Saroj Kumar Singh, Dr. Hitesh Bucha and Dr. Gautam Mandal
Abstract
In India Oral squamous cell carcinoma is the most common type of oral cancer (90%). The most common site of oral cancer is buccal mucosa. It has been observed that Vitamin A deficiency is associated with Squamous metaplasia in mucosa of upper aerodigestive tract. Present study intends to observe the estimate of Retinoic acid receptor-Beta expression in different grades of oral squamous cell carcinoma. Retinoic acid receptor-Beta expression is corelated with the grade of the tumor statistically.
Material and Methods: Study was conducted over a period of 2 year (Sep 2015-Sep 2017) on the specimen sent to pathology department of government medical college and hospital. It was studied histologically to assess the grade and then immunohistochemistry for RAR ß was performed.
Result: Study showed that 59.53% of cases belong to grade I followed by grade II (35.71) and grade III(4.76%).59.53% cases were positive for RAR ß and 40.47% cases were negative. There was significant association between grade of differentiation and status of RAR ß of the patients (p=0.0091). Proportion negativity of RAR ß increased with the increase in grade of differentiation.
Conclusion: A significant correlation was seen between the loss of RAR ß expression and advanced histopathological grade tumors of oral squamous cell carcinoma.
Pages: 90-92  |  707 Views  84 Downloads


International Journal of Applied Research
How to cite this article:
Dr. Deepika Pandey, Dr. Saroj Kumar Singh, Dr. Hitesh Bucha, Dr. Gautam Mandal. Study of the relationship between expression of Retinoic acid receptor: Beta by IHC in different grade of oral squamous cell carcinoma. Int J Appl Res 2020;6(4):90-92.
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