Vol. 8, Issue 12, Part C (2022)

Background: Platelet concentrates are autologous bioactive substances that have found multiple applications in the field of dentistry. The rationale behind this is to concentrate and extract certain elements from the patient’s own blood sample, which can be used to improve healing and promote tissue regeneration. Diabetics and smokers are also known to be at a much higher risk of periodontal disease and also show delayed wound healing. This may lead to the failure of periodontal regenerative therapy. PRF, may serve to accelerate the healing process and give an improved outcome since it contains concentrated platelets and WBCs which play a pivotal role in wound healing.

Aim: The aim of this study was to analyze the platelet and the leukocyte counts in the PRF and the size of the PRF membrane formed in order to determine whether diabetes and smoking has an impact on the PRF formation.

Material and Method: This is a clinical study in which 30 chronic periodontitis patients from the OPD were enrolled. The study consists of three groups. Group 1 (Control) comprised of 10 systemically healthy patients with chronic periodontitis, Group 2 (Test 1) comprised of 10 chronic smokers with chronic periodontitis and Group 3 (Test 2) comprised of 10 chronic diabetics with chronic periodontitis.

15 ml of blood was drawn from all subjects to assess the size outcome, platelet, and leukocyte concentration and the size of the PRF clot formed.

Results: Diabetics showed comparatively higher platelet and WBC counts and also showed larger PRF clot dimensions on measurement.

Conclusion: The increased blood sugar levels led to increase in the leukocyte and platelet activity. This could be beneficial for usage in regenerative procedures and treatment of periodontal defects.