Vol. 8, Issue 4, Part F (2022)

Abstract
Background: Rheumatoid arthritis is a miscellaneous and diversified disease, which established on causative factors i.e. combining genetic risk factors and antibodies, sub-classified into sero-positive and sero-negative RA. Positive ACPA and positive RF with rising CRP-levels in mostly patients occurs years before the starting of clinical symptoms indicate that compatible immunity start to develop very early for RA.Aim and Objectives: To assess improvement in the cases of RA using rare homeopathic medicine ; Ferrum picricum, Methylene blue, Salicylic acid on the basis of ACR response/2010/EULAR Diagnostic Criteria for Rheumatoid Arthritis which measures percentage improvement from baseline on the basis of joint involvement score, RA Factor, CRP value, ACPA value, ESR value and symptomatic changes.Material and Methods: Case Definition-Patient having the symptoms of Rheumatoid Arthritis considered on the basis of clinical presentations, a complete history taking, clinical examinations and lab investigations with no complications, case as per International Classification of Disease-10-CM Diagnostic Code M06.9. Study Area: The work has been done at Sri Ganganagar Homoeopathic Medical College, Hospital And Post Graduate Research Centre, Rajasthan, India, Out Patient Department (Opd), In Patient Department (Ipd) And Peripheral Centres Sample size-30 cases selected for each of 3 medicines (total 90) to be tested in proposed research by Random Sampling Method and each medicines will be serially tested in consecutive selected cases. Study Design: Each sign and symptoms of patients noted as per directions given by Dr. Samuel Hahnemann in Organon of Medicine (6th Edition). Every case will be represented according to the guidelines given in the Standardized Case Record. Symptoms and signs analyzed as per chronic disease by Dr. Samuel F. Hahnemann, totality would be erected and suitable remedy ; among the three remedies in Clarke’s Clinical Repertory given in clinical rubric- Rheumatoid Arthritis, administered. Base line investigations done in each case were clinical criteria – (early morning stiffness, joint tenderness, joint swelling,) serological test, acute phase response (ESR, CRP, RF, ANTI-CCP).Statistical Analysis: the stastical tool Paired T Test has been used for my research study. There is no comparative study, this was a prospective and clinical study. Analysis result was done with the help of Microsoft excel 2016, graph pad and calculator. Results: Three Homoeopathic drugs mentioned in Clarkes Repertory under clinical rubric Rheumatoid Arthritis were found to reduce joint involvement in 90 patients with RA; t value=19.0547, P<.001 (for ferrum pic; n=30, paired t value = 8.86, for methylene blue; n=30, paired t value = 13.87, for salicylic acid; n=30, t=15.33; P< 0.001). The 2010 ACR/EULAR Diagnostic score reduced in all 90 patients t=22.38063; P< 0.001 (30 patients for ferrum pic t= 11.32, 30 patients for methylene blue t= 14.05,30 patients for salicylic acid t= 13.05; P< 0.001). Mean ESR improved to 18.51 from 29.11 (t = 20.10144, P< 0.05). Out of 90, 31 (34.44%) patients were found to be Sero-negative after given three Homoeopathic drug- Ferrum Picricum, Methylene Blue and Salicylic Acid. Psora- Sycosis is the dominant miasm mostly found among 90 Rheumatic Arthritis patients. Conclusion: In my study i.e. “Efficacy of Homoeopathy using Clarke’s Clinical Repertory in cases of Rheumatoid Arthritis by testing the indicated medicines in given related Clinical Rubric”; the foregone conclusion of my study satisfied my research hypothesis so remarkably when we studied the cases after 6 month of treatment and drugs given.