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International Journal of Applied Research
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ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF

IMPACT FACTOR (RJIF): 8.4

Vol. 8, Issue 8, Part E (2022)

Biomarkers for diagnosis of sepsis and their role in sepsis management: A brief review

Biomarkers for diagnosis of sepsis and their role in sepsis management: A brief review

Author(s)
Ekta Gupta, Eshank Gupta, PC Gupta and Prabhu Prakash
Abstract
A marker of sepsis has been defined as “a measure that identifies a normal biologic state or that predicts the presence or severity of a pathologic process or disease.”
Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific therapies or assessing the response to therapy.
Biomarkers can have an important place in this process because they can indicate the presence or absence or severity of sepsis and can differentiate bacterial from viral and fungal infection, and systemic sepsis from local infection. Other potential uses of biomarkers include roles in prognostication, guiding antibiotic therapy, evaluating the response to therapy and recovery from sepsis, differentiating Gram-positive from Gram-negative microorganisms as the cause of sepsis, predicting sepsis complications and the development of organ dysfunction (heart, kidneys, liver or multiple organ dysfunction). However, the exact role of biomarkers in the management of septic patients remains . C-reactive protein (CRP) has been used for many years but its specificity has been challenged Procalcitonin (PCT) has been proposed as a more specific and better prognostic marker than CRP, although its value has also been challenged. It remains difficult to differentiate sepsis from other non-infectious causes of systemic inflammatory response syndrome, and there is a continuous search for better biomarkers of sepsis.
Pages: 336-339  |  291 Views  69 Downloads


International Journal of Applied Research
How to cite this article:
Ekta Gupta, Eshank Gupta, PC Gupta, Prabhu Prakash. Biomarkers for diagnosis of sepsis and their role in sepsis management: A brief review. Int J Appl Res 2022;8(8):336-339.
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