Vol. 8, Issue 9, Part A (2022)

Background: Tooth regeneration as an idea was debatable and improbable. Anti USAG-1 is being widely discussed as a breakthrough for tooth regeneration. Uterine sensitisation associated with gene-1 is a protein thought to influence the teeth' regeneration indirectly. USAG-1 acts on BMP-7 (bone morphogenetic protein-7) protein, inhibiting its action and hindering teeth regeneration. Suppressing the said protein has been shown to promote supernumerary tooth formation in mice. Animal studies are undergoing tremendous breakthroughs, and soon human trials can be initiated. USAG-1 suppression can provide a new curative treatment plan for edentulous and anodontia patients.

Aim: To evaluate the effectiveness of anti-USAG therapy for tooth regeneration.

Method: A literature search was performed using PubMed, Cochrane central register of controlled trials (CENTRAL), science direct, Wiley, and PMC using MeSH Terms-Anti USAG-, tooth regeneration. Of 108 articles screened, eight full-text articles were assessed for eligibility, and five articles were taken for the qualitative analysis. This review was outlined according to the PRISMA guidelines.

Results: Articles collected showed positive effects of Anti USAG-1 inducing supernumerary teeth formation in genetically modified mice models.

Conclusion: In the available literature, anti-USAG-1 can stimulate third dentition or induce teeth regeneration in mammals.