Vol. 9, Issue 2, Part E (2023)

Acrokeratoelastoidosis is a rare genodermatosis of unclear cause. It usually begins in childhood or adolescence and is clinically characterized by multiple small, firm, yellowish papules on the lateral borders of the hands and feet. There are several differential diagnoses that histology excludes by showing elastorrhexis associated with hyperkeratosis and acanthosis. The aesthetic prejudice caused by this condition can be important in some patients, justifying a treatment but to date none is satisfactory.