Vol. 10, Issue 4, Part E (2024)

Abstract
Oral health surveys exhibit that even in countries with established oral hygiene practices, most people have relatively poor gum health. This is due to low interest in compliance with oral hygiene procedures. When examining compliance with oral hygiene habits, a number of factors stand out. Only about 50% of the population brushes their teeth more than once a day, brushing time is probably too short, and flossing is not very common. Many product forms are available to provide anti-plaque agents, including mouthwash, toothpaste, water-based gels, as well as dental floss, chewing gum, and lozenges. Each product form must provide a physically, chemically, and microbiologically stable environment for the intended active ingredient which aimed at allowing optimal bioavailability of the active ingredient at the site of action and promoting patient compliance. Antiplaque agents for topical administration must possess the following properties: high specific efficacy against a wide range of oral microorganisms, toxicological and environmental safety, oral persistence, absence of side effects, and Good chemical stability. Many classes of antiplaque agents have been identified, including positively charged organic molecules, metal salts, phenols, enzymes, peroxides, sugar substitutes, fluorides, and surface modifiers. To achieve optimal bioavailability, the administered drug must be compatible with the form of the product used. There are two main product forms: rinse and toothpaste.